The Development, Commercialization, and Impact of Optical Coherence Tomography
نویسندگان
چکیده
This review was written for the special issue of IOVS to describe the history of optical coherence tomography (OCT) and its evolution from a nonscientific, historic perspective. Optical coherence tomography has become a standard of care in ophthalmology, providing real-time information on structure and function - diagnosing disease, evaluating progression, and assessing response to therapy, as well as helping to understand disease pathogenesis and create new therapies. Optical coherence tomography also has applications in multiple clinical specialties, fundamental research, and manufacturing. We review the early history of OCT describing how research and development evolves and the important role of multidisciplinary collaboration and expertise. Optical coherence tomography had its origin in femtosecond optics, but used optical communications technologies and required advanced engineering for early OCT prototypes, clinical feasibility studies, entrepreneurship, and corporate development in order to achieve clinical acceptance and clinical impact. Critical advances were made by early career researchers, clinician scientists, engineering experts, and business leaders, which enabled OCT to have a worldwide impact on health care. We introduce the concept of an "ecosystem" consisting of research, government funding, collaboration and competition, clinical studies, innovation, entrepreneurship and industry, and impact - all of which must work synergistically. The process that we recount is long and challenging, but it is our hope that it might inspire early career professionals in science, engineering, and medicine, and that the clinical and research community will find this review of interest.
منابع مشابه
Development of an Advanced Optical Coherence Tomography System for Radiation Dosimetry
Introduction: According to the literature, optical coherence tomography (OCT) can be used measure radiation absorbed dose. This study was carried out to design a computed tomography system for the calculation of absorbed dose and optimization of dose delivery in radiotherapy using gel dosimeters. Material and Methods: An advanced charge-coupled device based OCT system was developed in laborator...
متن کاملClinical Applications of Optical Coherence Tomography in Ophthalmology
Assessment of the peripapillary nerve fiber layer and macular thickness can be determined in ophthalmology using optical coherence tomography (OCT). Decreased nerve fiber layer thickness and macular ganglion cell thickness in optic nerve ischemia have been correlated with visual field loss. OCT allows deep optic nerve head evaluation which helps understand pathophysiology of diseases. Furtherm...
متن کاملCorrelation between Visual Acuity and Optical Coherence Tomography-Measured Retinal Thickness in Diabetic Macular Edema
Background and Objective: Diabetic macular edema (DME) is one of the common complications of diabetes which significantly accounts for preventable visual impairment and blindness. Central macular thickness (CMT) is a feature found in DME patients. This study aims to determine the relationship between optical coherence tomography (OCT)-measured CMT and visual acuity (VA) in patients with DME bef...
متن کاملExperimental Visualization of Labyrinthine Structure with Optical Coherence Tomography
Introduction:Visualization of inner ear structures is a valuable strategy for researchers and clinicians working on hearing pathologies. Optical coherence tomography (OCT) is a high-resolution imaging technology which may be used for the visualization of tissues. In this experimental study we aimed to evaluate inner ear anatomy in well-prepared human labyrinthine bones.Materials and Methods:Thr...
متن کاملComparison of Choroidal Thickness in Psoriasis and Control Groups Using Optical Coherence Tomography
Background and Objective: One of the most common extracutaneous complications in psoriasis patients is ocular complications, which is controversial concerning its effect on choroidal thickness. This study aimed to compare the psoriasis patients with healthy individuals in terms of the thickness of the choroidal layer using the optical coherence tomography technique. Materials and Methods: In t...
متن کامل